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KMID : 1039420220560030152
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Journal of Pathology and Translational Medicine
2022 Volume.56 No. 3 p.152 ~ p.156
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A sinonasal yolk sac tumor in an adult
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Shin Jae-Hoon
Kim Ji-Heui
Jung Kyeong-Cheon
Cho Kyung-Ja
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Abstract
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Yolk sac tumors (YSTs), which are also called endodermal sinus tumors, are malignant tumors of germ cell origin. These tumors usually occur in the gonads, but 20% of cases have been reported at extragonadal sites. The head and neck is a rarely affected region that accounts for just 1% of all malignant tumors of germ cell origin. In addition, YSTs arise mostly in childhood. We present a rare pathologically pure case of primary adult YST in the sinonasal area. A 45-year-old male patient presented with a rapidly growing mass in the nasal cavity, which caused nasal obstruction and bloody post-nasal drip. The histopathologic features indicated pure YST, and immunohistochemical analysis revealed positive reactivity for Sal-like protein 4 and alpha-fetoprotein. Herein, we discuss the clinical, radiologic, and histologic features of this YST and review other cases of sinonasal YST in adults.
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KEYWORD
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Yolk sac tumor, Endodermal sinus tumor, Paranasal sinus, Nasal cavity, Adult
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